Id: acc4791
Group: 1sens
Protein: VGLL4
Gene Symbol: VGLL4
Protein Id: Q14135
Protein Name: VGLL4_HUMAN
PTM: acetylation
Site: unclear
Site Sequence:
Disease Category: Cardiovascular and circulatory system diseases
Disease: Pulmonary Hypertension
Disease Subtype: chronic normobaric hypoxia (CNH)-induced
Disease Cellline: PASMCs
Disease Info:
Drug: resveratrol
Drug Info: "Resveratrol is a polyphenolic compound found in various plants, known for its potential antioxidant and anti - inflammatory properties."
Effect: modulate
Effect Info: "Blocking VGLL4 acetylation by resveratrol can reverse CNH-induced pulmonary hypertension (PH) and pulmonary artery remodeling, as well as the expression of proliferation- and apoptosis-related proteins in the lung tissues of mice."
Note:
Score: 4.0
Pubmed(PMID): 34314061
Sentence Index:
Sentence:

Sequence & Structure:

METPLDVLSRAASLVHADDEKREAALRGEPRIQTLPVASALSSHRTGPPPISPSKRKFSMEPGDEDLDCDNDHVSKMSRIFNPHLNKTANGDCRRDPRERSRSPIERAVAPTMSLHGSHLYTSLPSLGLEQPLALTKNSLDASRPAGLSPTLTPGERQQNRPSVITCASAGARNCNLSHCPIAHSGCAAPGPASYRRPPSAATTCDPVVEEHFRRSLGKNYKEPEPAPNSVSITGSVDDHFAKALGDTWLQIKAAKDGASSSPESASRRGQPASPSAHMVSHSHSPSVVS

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: