| Id: | acc4792 |
| Group: | 1sens |
| Protein: | p65 |
| Gene Symbol: | Rela |
| Protein Id: | Q04207 |
| Protein Name: | TF65_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser536 |
| Site Sequence: | SGDEDFSSIADMDFSALLSQI |
| Disease Category: | Immune system diseases |
| Disease: | Atopic Dermatitis |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | gomisin M2 (GM2) |
| Drug Info: | Gomisin M2 (GM2) is a drug that may have certain pharmacological activities and potential applications in medical research. |
| Effect: | modulate |
| Effect Info: | GM2 can inhibit the phosphorylation of STAT1 and NF-κB p65 in atopic dermatitis (AD) and ultimately suppress AD. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 34361560 |
| Sentence Index: | 34361560_5 |
| Sentence: | "GM2 suppressed the expression of IL-1beta, IL-4, IL-5, IL-6, IL-12a, and TSLP in ear tissue and the expression of IFN-gamma, IL-4, and IL-17A in auricular lymph nodes." |
Sequence & Structure:
MDDLFPLIFPSEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGYYEADLCPDRSIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFHVPIEEQRGDYDLNAVRLCFQVTVRDPAGRPLLLTPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFNGPTEPRPPTRRIAVPTRNSTSVPKPAPQPYTFPASLSTINFDEFSPMLLPSGQISNQALALAPSSAPVLAQTMVPSSAMVPLAQPPAPAPVLTPGPPQSLSAPVPKSTQAGEGTLSEALLHLQFDADEDLGALLGNSTDPGVFTDLASVDNSEFQQLLNQGVSMSHSTAEPMLMEYPEAITRLVTGSQRPPDPAPTPLGTSGLPNGLSGDEDFSSIADMDFSALLSQISS
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
