| Id: | acc4813 |
| Group: | 1sens |
| Protein: | Nrf2 |
| Gene Symbol: | Nfe2l2 |
| Protein Id: | Q60795 |
| Protein Name: | NF2L2_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser40 |
| Site Sequence: | GVSREVFDFSQRQKDYELEKQ |
| Disease Category: | Digestive system diseases |
| Disease: | Intestinal Barrier Injury |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Morchella importuna?Flavones |
| Drug Info: | Morchella importuna Flavones is a drug. It may have certain pharmacological activities and potential therapeutic effects. |
| Effect: | modulate |
| Effect Info: | Morel flavonoids improve DSS-induced intestinal barrier damage by reducing NF-κB phosphorylation (inhibiting inflammation) and increasing Nrf2 phosphorylation (activating antioxidant capacity). |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 34552579 |
| Sentence Index: | 34552579_9 |
| Sentence: | "Meanwhile, MIF ingestion reduced (p < 0.05) the colonic interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) concentrations and increased the superoxide dismutase and catalase activities and Shannon and Simpson indices in DSS-challenged mice." |
Sequence & Structure:
MMDLELPPPGLQSQQDMDLIDILWRQDIDLGVSREVFDFSQRQKDYELEKQKKLEKERQEQLQKEQEKAFFAQFQLDEETGEFLPIQPAQHIQTDTSGSASYSQVAHIPKQDALYFEDCMQLLAETFPFVDDHESLALDIPSHAESSVFTAPHQAQSLNSSLEAAMTDLSSIEQDMEQVWQELFSIPELQCLNTENKQLADTTAVPSPEATLTEMDSNYHFYSSISSLEKEVGNCGPHFLHGFEDSFSSILSTDDASQLTSLDSNPTLNTDFGDEFYSAFIAEPSDGGSMPSSAAISQSLSELLDGTIEGCDLSLCKAFNPKHAEGTMEFNDSDSGISLNTSPSRASPEHSVESSIYGDPPPGFSDSEMEELDSAPGSVKQNGPKAQPAHSPGDTVQPLSPAQGHSAPMRESQCENTTKKEVPVSPGHQKAPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVDDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLGHLKDEREKLLREKGENDRNLHLLKRRLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKPDTKKN
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
