| Id: | acc4815 |
| Group: | 1sens |
| Protein: | AMPKalpha |
| Gene Symbol: | Prkaa1 |
| Protein Id: | Q5EG47 |
| Protein Name: | AAPK1_MOUSE |
| PTM: | phosphorylation |
| Site: | Thr172 |
| Site Sequence: | NAKIADFGLSNMMSDGEFLRT |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Metabolic Disease |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | 18:0 Lyso PC |
| Drug Info: | The drug is Lyso PC with a concentration (possibly) indicated by 18:0. |
| Effect: | modulate |
| Effect Info: | "The drug activates the phosphorylation of AMPKα and ACC, thereby inhibiting fatty acid synthesis and alleviating metabolic syndrome." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 34607170 |
| Sentence Index: | 34607170_7 |
| Sentence: | "The mechanism, by which this natural compound alleviates metabolic syndrome, involves a reduction in fatty acid synthesis mediated by activation of the phosphorylation of adenosine 5'-monophosphate (AMP)-activated protein kinase-alpha (AMPKalpha) and acetyl-CoA carboxylase (ACC) and an increase expression of uncoupled protein 1 (UCP1) and PPAR-gamma coactivator-1 alpha (PGC1-alpha)." |
Sequence & Structure:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRAAIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSISNYRSCQRSDSDAEAQGKPSDVSLTSSVTSLDSSPVDVAPRPGSHTIEFFEMCANLIKILAQ
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
