| Id: | acc4818 |
| Group: | 1sens |
| Protein: | CypD |
| Gene Symbol: | PPID |
| Protein Id: | Q08752 |
| Protein Name: | PPID_HUMAN |
| PTM: | acetylation |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Cell stress and damage |
| Disease: | Damage In Chondrocytes |
| Disease Subtype: | Mitochondrial Dysfunction |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Rg3 |
| Drug Info: | "Rg3 is a compound often extracted from ginseng, which may have various potential health - promoting effects. " |
| Effect: | modulate |
| Effect Info: | "Ginsenoside Rg3 inhibits TNF-α-induced CypD acetylation by activating the SIRT1/PGC-1α/SIRT3 signaling pathway, alleviates mitochondrial damage and oxidative stress, improves TNF-α-induced apoptosis, and thus relieves symptoms." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 34943075 |
| Sentence Index: | 34943075_10 |
| Sentence: | "Moreover, the activation of the SIRT1/PGC-1alpha/SIRT3 pathway by Rg3 suppressed the TNF-alpha-induced acetylation of CypD, resulting in less mitochondrial dysfunction and accumulation of reactive oxygen species (ROS)." |
Sequence & Structure:
MSHPSPQAKPSNPSNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGHTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDREGLLSMANAGRNTNGSQFFITTVPTPHLDGKHVVFGQVIKGIGVARILENVEVKGEKPAKLCVIAECGELKEGDDGGIFPKDGSGDSHPDFPEDADIDLKDVDKILLITEDLKNIGNTFFKSQNWEMAIKKYAEVLRYVDSSKAVIETADRAKLQPIALSCVLNIGACKLKMSNWQGAIDSCLEALELDPSNTKALYRRAQGWQGLKEYDQALADLKKAQGIAPEDKAIQAELLKVKQKIKAQKDKEKAVYAKMFA
No data.
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTAC| PPID-Lys111 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.707 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | 0.707 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
