| Id: | acc4819 |
| Group: | 1sens |
| Protein: | Drp1 |
| Gene Symbol: | Dnm1l |
| Protein Id: | Q8K1M6 |
| Protein Name: | DNM1L_MOUSE |
| PTM: | phosphorylation |
| Site: | Tyr628 |
| Site Sequence: | KGHAVNLLDVPVPVARKLSAR |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Aortic Valve Calcificatio |
| Disease Subtype: | |
| Disease Cellline: | VICs |
| Disease Info: | |
| Drug: | Tetrahydrobiopterin (BH4) |
| Drug Info: | Tetrahydrobiopterin (BH4) is a naturally occurring essential cofactor for a set of enzymes involved in various physiological processes. It plays a crucial role in neurotransmitter synthesis and nitric oxide production. |
| Effect: | modulate |
| Effect Info: | Tyrosine nitration of DRP1 promotes valve calcification. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 35139535 |
| Sentence Index: | 35139535_11 |
| Sentence: | "The reduction in endothelial-dependent BH4 levels promoted peroxynitrite formation, which subsequently resulted in DRP1 tyrosine nitration and osteoblastic differentiation of VICs, thereby leading to aortic valve calcification." |
Sequence & Structure:
MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAGSRDKSSKVPSALAPASQEPPPAASAEADGKLIQDNRRETKNVPSAGGGIGDGGQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
