| Id: | acc4821 |
| Group: | 1sens |
| Protein: | IkappaBalpha |
| Gene Symbol: | Nfkbia |
| Protein Id: | Q63746 |
| Protein Name: | IKBA_RAT |
| PTM: | phosphorylation |
| Site: | Ser32 |
| Site Sequence: | ERLVDDRHDSGLDSMKDEDYE |
| Disease Category: | Immune system diseases |
| Disease: | Allergic |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | "3,4-dihydroxybenzaldehyde (DHB)" |
| Drug Info: | "3,4-dihydroxybenzaldehyde (DHB) is a chemical compound, which may have potential applications in the field of medicine. " |
| Effect: | modulate |
| Effect Info: | "DHB significantly inhibits the phosphorylation of IκBα stimulated by IgE/BSA, thereby preventing the translocation of NF-κB from the cytoplasm to the nucleus, reducing the expression of various sensitizing cytokines (such as IL-4, IL-5, TNF-α), and alleviating type I allergic reactions." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 35200662 |
| Sentence Index: | 35200662_4 |
| Sentence: | "Moreover, DHB suppressed the secretion and/or the expression of the allergic cytokines, interleukin (IL)-4, IL-5, IL-6, IL-13, and tumor necrosis factor (TNF)-alpha, and the chemokine, thymus activation-regulated chemokine (TARC), by regulating the phosphorylation of IkappaBalpha and the translocation of cytoplasmic NF-kappaB into the nucleus." |
Sequence & Structure:
MFQPAGHGQDWAMEGPRDGLKKERLVDDRHDSGLDSMKDEDYEQMVKELREIRLQPQEAPLAAEPWKQQLTEDGDSFLHLAIIHEEKTLTMEVIGQVKGDLAFLNFQNNLQQTPLHLAVITNQPGIAEALLKAGCDPELRDFRGNTPLHLACEQGCLASVAVLTQTCTPQHLHSVLQATNYNGHTCLHLASIHGYLGIVEHLVTLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQTLPESEDEESYDTESEFTEDELPYDDCVFGGQRLTL
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
