Id: | acc4822 |
Group: | 1sens |
Protein: | ULK1 |
Gene Symbol: | Ulk1 |
Protein Id: | O70405 |
Protein Name: | ULK1_MOUSE |
PTM: | ubiquitination |
Site: | unclear |
Site Sequence: | |
Disease Category: | Cardiovascular and circulatory system diseases |
Disease: | Cardiac Infarction |
Disease Subtype: | |
Disease Cellline: | |
Disease Info: | |
Drug: | TRAF3 OE |
Drug Info: | "TRAF3 OE is a substance that might be relevant to gene over - expression of TRAF3, and it could have potential implications in biological research and disease - related studies. " |
Effect: | modulate |
Effect Info: | TRAF3 promotes oxidative stress in a ROS-induced myocardial infarction model by regulating ULK1 ubiquitination. |
Note: | Non-conventional drugs |
Score: | 3.0 |
Pubmed(PMID): | 35318880 |
Sentence Index: | 35318880_0 |
Sentence: | TRAF3 promoted ROS-induced oxidative stress in model of cardiac infarction through the regulation of ULK1 ubiquitination. |
Sequence & Structure:
MEPGRGGVETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTVRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPAIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASTPIKKSPPVPVPSYPSSGSGSSSSSSSASHLASPPSLGEMPQLQKTLTSPADAAGFLQGSRDSGGSSKDSCDTDDFVMVPAQFPGDLVAEAASAKPPPDSLLCSGSSLVASAGLESHGRTPSPSPTCSSSPSPSGRPGPFSSNRYGASVPIPVPTQVHNYQRIEQNLQSPTQQQTARSSAIRRSGSTTPLGFGRASPSPPSHTDGAMLARKLSLGGGRPYTPSPQVGTIPERPSWSRVPSPQGADVRVGRSPRPGSSVPEHSPRTTGLGCRLHSAPNLSDFHVVRPKLPKPPTDPLGATFSPPQTSAPQPCPGLQSCRPLRGSPKLPDFLQRSPLPPILGSPTKAGPSFDFPKTPSSQNLLTLLARQGVVMTPPRNRTLPDLSEASPFHGQQLGSGLRPAEDTRGPFGRSFSTSRITDLLLKAAFGTQASDSGSTDSLQEKPMEIAPSAGFGGTLHPGARGGGASSPAPVVFTVGSPPSGATPPQSTRTRMFSVGSSSSLGSTGSSSARHLVPGACGEAPELSAPGHCCSLADPLAANLEGAVTFEAPDLPEETLMEQEHTETLHSLRFTLAFAQQVLEIAALKGSASEAAGGPEYQLQESVVADQISQLSREWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLSSTVKQVVRRLNELYKASVVSCQGLSLRLQRFFLDKQRLLDGIHGVTAERLILSHAVQMVQSAALDEMFQHREGCVPRYHKALLLLEGLQHTLTDQADIENIAKCKLCIERRLSALLSGVYA
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDResidue | Position | State | Disease | Class | PMID |
---|---|---|---|---|---|
S | 555 | D | Dilated cardiomyopathy | Phosphorylation | 30511961 |
R | 170 | U | Glioblastoma multiforme | Methylation | 35246531 |
S | 405 | U | Pancreatic ductal adenocarcinoma | Phosphorylation | 33654220 |
S | 415 | U | Pancreatic ductal adenocarcinoma | Phosphorylation | 33654220 |
S | 555 | U | Alzheimer's disease | Phosphorylation | 37231161 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.