| Id: | acc4839 |
| Group: | 1sens |
| Protein: | Smad3 |
| Gene Symbol: | Smad3 |
| Protein Id: | P84025 |
| Protein Name: | SMAD3_RAT |
| PTM: | phosphorylation |
| Site: | Ser425 |
| Site Sequence: | SPSIRCSSVS----------- |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Cardiac Inflammation and Fibrosis |
| Disease Subtype: | |
| Disease Cellline: | T2DM rat |
| Disease Info: | |
| Drug: | Gentiopicroside |
| Drug Info: | "Gentiopicroside is a bioactive compound found in certain plants, which has anti - inflammatory and other potential pharmacological effects." |
| Effect: | modulate |
| Effect Info: | Gentiopicroside alleviates cardiac inflammation and fibrosis in T2DM rats by targeting Smad3 phosphorylation. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 36037771 |
| Sentence Index: | 36037771_0 |
| Sentence: | Gentiopicroside alleviates cardiac inflammation and fibrosis in T2DM rats through targeting Smad3 phosphorylation. |
Sequence & Structure:
MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
