| Id: | acc4843 |
| Group: | 1sens |
| Protein: | Drp1 |
| Gene Symbol: | Dnm1l |
| Protein Id: | Q8K1M6 |
| Protein Name: | DNM1L_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser637 |
| Site Sequence: | VPVPVARKLSAREQRDCEVIE |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Mitochondrial Dysfunction |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Akap1 knockout |
| Drug Info: | "Akap1 knockout refers to the absence or inactivation of the Akap1 gene, which may be used in research to understand the function of Akap1 in biological processes." |
| Effect: | modulate |
| Effect Info: | "Akap1 knockout leads to a significant reduction in phosphorylation at the PKA target site Ser637 and a decrease in phosphorylation of Akt at Ser473, increasing the risk of mitochondrial dysfunction." |
| Note: | Non-conventional drugs |
| Score: | 3.0 |
| Pubmed(PMID): | 36263130 |
| Sentence Index: | 36263130_15 |
| Sentence: | "Mechanistically, a significant loss of dynamin-related protein 1 (Drp1) phosphorylation at the protein kinase A (PKA) site Serine 637 (Ser637), decreases in Akt phosphorylation at Serine 437 (Ser47) and increase in the expression of pro-apoptotic protein Bax indicate mitochondrial dysfunction." |
Sequence & Structure:
MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAGSRDKSSKVPSALAPASQEPPPAASAEADGKLIQDNRRETKNVPSAGGGIGDGGQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
