| Id: | acc4848 |
| Group: | 1sens |
| Protein: | STAT4? |
| Gene Symbol: | Stat4 |
| Protein Id: | P42228 |
| Protein Name: | STAT4_MOUSE |
| PTM: | phosphorylation |
| Site: | Tyr693 |
| Site Sequence: | SRPTERGDKGYVPSVFIPIST |
| Disease Category: | Immune system diseases |
| Disease: | Asthma |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | PQQ |
| Drug Info: | PQQ is a naturally - occurring quinone compound that may have potential health benefits such as improving mitochondrial function. |
| Effect: | modulate |
| Effect Info: | "PQQ inhibits the phosphorylation of STAT1, STAT3, and STAT6 and promotes the phosphorylation of STAT4, ultimately effectively alleviating allergic airway inflammation in mice." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 36345503 |
| Sentence Index: | 36345503_9 |
| Sentence: | "PQQ administration also changed the secretion of IFN-gamma and IL-4 as well as the percentages of Th1, Th2, Th17, and Treg cells in the peripheral blood and lung tissues, along with inhibition the phosphorylation of STAT1, STAT3, and STAT6 while promoting that of STAT4 in allergic airway inflammation model mice." |
Sequence & Structure:
MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIETQDWEVASNNETMATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAANMPIQGPLEKSLQSSSVSERQRNVEHKVSAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQTMDQGDKNSILVNQEVLTLLQEMLNSLDFKRKEALSKMTQIVNETDLLMNSMLLEELQDWKKRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRQQLEKLQEQSTKMTYEGDPIPAQRAHLLERATFLIYNLFKNSFVVERQPCMPTHPQRPMVLKTLIQFTVKLRLLIKLPELNYQVKVKASIDKNVSTLSNRRFVLCGTHVKAMSSEESSNGSLSVEFRHLQPKEMKCSTGSKGNEGCHMVTEELHSITFETQICLYGLTINLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPSVTLGQLLEVMSWQFSSYVGRGLNSEQLNMLAEKLTVQSNYNDGHLTWAKFCKEHLPGKTFTFWTWLEAILDLIKKHILPLWIDGYIMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDQSENGEVRFHSVEPYNKGRLSALAFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTERGDKGYVPSVFIPISTIRSDSTEPQSPSDLLPMSPSAYAVLRENLSPTTIETAMNSPYSAE
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
