Id: | acc4867 |
Group: | 1sens |
Protein: | p70S6K |
Gene Symbol: | Rps6kb1 |
Protein Id: | P67999 |
Protein Name: | KS6B1_RAT |
PTM: | phosphorylation |
Site: | Ser389 |
Site Sequence: | SQFDSKFTRQTPVDSPDDSTL |
Disease Category: | Cardiovascular and circulatory system diseases |
Disease: | Cardiac Hypertrophy |
Disease Subtype: | |
Disease Cellline: | NNVMs |
Disease Info: | |
Drug: | Rapamycin |
Drug Info: | Rapamycin is a macrolide compound that is used as an immunosuppressant and has potential applications in treating various diseases such as cancer and aging-related conditions. |
Effect: | modulate |
Effect Info: | Rapamycin exerts its anti - hypertrophic effect by inhibiting the phosphorylation of p70S6K and regulating the expression of SUR2A protein. |
Note: | |
Score: | 4.0 |
Pubmed(PMID): | 36988388 |
Sentence Index: | 36988388_8 |
Sentence: | "Rapamycin pretreatment of phorbol 12,13-dibutyrate (PDBu)-treated neonatal rat ventricular cardiomyocytes (NNVMs) suppressed hypertrophy, inhibited p70S6K phosphorylation, and attenuated SUR2A protein upregulation." |
Sequence & Structure:
MRRRRRRDGFYPAPDFRHREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTTSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.