| Id: | acc4877 |
| Group: | 1sens |
| Protein: | p53? |
| Gene Symbol: | Tp53 |
| Protein Id: | P02340 |
| Protein Name: | P53_MOUSE |
| PTM: | acetylation |
| Site: | Lys382 |
| Site Sequence: | STSRHKKTMVKKVGPDSD--- |
| Disease Category: | Urinary and reproductive system diseases |
| Disease: | Acute Kidney Injury |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Baicalein? |
| Drug Info: | Baicalein is a flavonoid compound that is extracted from the roots of Scutellaria baicalensis and has various pharmacological activities. |
| Effect: | modulate |
| Effect Info: | Baicalein inhibits PMB-induced ferroptosis and alleviates acute kidney injury (AKI) by upregulating SIRT1 expression and reducing the acetylation level of p53 at the K382 site. This mechanism indicates the key regulatory role of p53 K382 acetylation in the occurrence and development of AKI and reveals the potential of baicalein as an intervention method. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 37354967 |
| Sentence Index: | 37354967_0 |
| Sentence: | Baicalein ameliorates polymyxin B-induced acute renal injury by inhibiting ferroptosis via regulation of SIRT1/p53 acetylation. |
Sequence & Structure:
MTAMEESQSDISLELPLSQETFSGLWKLLPPEDILPSPHCMDDLLLPQDVEEFFEGPSEALRVSGAPAAQDPVTETPGPVAPAPATPWPLSSFVPSQKTYQGNYGFHLGFLQSGTAKSVMCTYSPPLNKLFCQLAKTCPVQLWVSATPPAGSRVRAMAIYKKSQHMTEVVRRCPHHERCSDGDGLAPPQHLIRVEGNLYPEYLEDRQTFRHSVVVPYEPPEAGSEYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENFRKKEVLCPELPPGSAKRALPTCTSASPPQKKKPLDGEYFTLKIRGRKRFEMFRELNEALELKDAHATEESGDSRAHSSYLKTKKGQSTSRHKKTMVKKVGPDSD
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
