| Id: | acc4878 |
| Group: | 1sens |
| Protein: | eIF2alpha |
| Gene Symbol: | Eif2s1 |
| Protein Id: | P68101 |
| Protein Name: | IF2A_RAT |
| PTM: | phosphorylation |
| Site: | Ser51 |
| Site Sequence: | IEGMILLSELSRRRIRSINKL |
| Disease Category: | Nervous system diseases |
| Disease: | Neuronal Injury |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | ISRIB |
| Drug Info: | ISRIB is a drug that may have potential applications in various biological and medical fields. |
| Effect: | modulate |
| Effect Info: | ISRIB can alleviate high-glucose-induced neuronal damage by reducing the phosphorylation of eIF2α. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 37410333 |
| Sentence Index: | 37410333_5 |
| Sentence: | ISRIB alleviated high glucose-induced neuronal injury by reducing eIF2alpha phosphorylation when neurons were pretreated with ISRIB before high glucose treatment. |
Sequence & Structure:
MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTETMPIKINLIAPPRYVMTTTTLERTEGLSVLNQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQLERLERENAEVDGDDDAEEMEAKAED
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
