| Id: | acc4880 |
| Group: | 1sens |
| Protein: | NF-kappaB p65 |
| Gene Symbol: | Rela |
| Protein Id: | Q04207 |
| Protein Name: | TF65_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser536 |
| Site Sequence: | SGDEDFSSIADMDFSALLSQI |
| Disease Category: | Immune system diseases |
| Disease: | Colitis |
| Disease Subtype: | ulcerative colitis |
| Disease Cellline: | Caco-2 |
| Disease Info: | |
| Drug: | Loganic acid |
| Drug Info: | Loganic acid is a natural compound that may have potential pharmacological activities. It is often found in certain plants. |
| Effect: | modulate |
| Effect Info: | "LA significantly inhibits intracellular ROS levels and NF-κB phosphorylation in both RAW 264.7 and Caco-2 cells, alleviates inflammation, and thus relieves ulcerative colitis." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 37421777 |
| Sentence Index: | 37421777_8 |
| Sentence: | "In DSS-induced colitis mice, LA significantly alleviated the inflammation and colonic damage by decreasing the pro-inflammatory cytokines (IL-1beta, IL-6, TNF-alpha, and IFN-gamma), oxidative stress markers (MDA, and NO), and also expression levels of various inflammatory proteins (TLR4 and NF-kB) which was evidenced by immunoblotting." |
Sequence & Structure:
MDDLFPLIFPSEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGYYEADLCPDRSIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFHVPIEEQRGDYDLNAVRLCFQVTVRDPAGRPLLLTPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFNGPTEPRPPTRRIAVPTRNSTSVPKPAPQPYTFPASLSTINFDEFSPMLLPSGQISNQALALAPSSAPVLAQTMVPSSAMVPLAQPPAPAPVLTPGPPQSLSAPVPKSTQAGEGTLSEALLHLQFDADEDLGALLGNSTDPGVFTDLASVDNSEFQQLLNQGVSMSHSTAEPMLMEYPEAITRLVTGSQRPPDPAPTPLGTSGLPNGLSGDEDFSSIADMDFSALLSQISS
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
