| Id: | acc4902 |
| Group: | 1sens |
| Protein: | GSK3beta |
| Gene Symbol: | Gsk3b |
| Protein Id: | P18266 |
| Protein Name: | GSK3B_RAT |
| PTM: | phosphorylation |
| Site: | Ser9 |
| Site Sequence: | -MSGRPRTTSFAESCKPVQQP |
| Disease Category: | Nervous system diseases |
| Disease: | Psychiatric Disorders |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Lithium |
| Drug Info: | Lithium is a chemical element and a mood - stabilizing medication. It is commonly used in the treatment of bipolar disorder to help control mood swings. |
| Effect: | modulate |
| Effect Info: | "Lithium increases the phosphorylation of GSK3beta at the Ser9 site, inhibits its activity, thereby reducing the degradation of beta-catenin and promoting the expression of the GluN2A subunit, which helps to improve cognitive impairment." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 29449801 |
| Sentence Index: | 29449801_3 |
| Sentence: | "Lithium, a clinically relevant drug commonly prescribed as a mood stabilizer for psychiatric disorders, significantly increased levels of phosphorylated GSK3beta serine 9, an inhibitory phosphorylation site, and decreased beta-catenin ser33/37/thr41 phosphorylation in vitro, indicating GSK3beta inhibition and reduced beta-catenin degradation." |
Sequence & Structure:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDMWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPANATAASDTNAGDRGQTNNAASASASNST
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
