Id: acc4907
Group: 1sens
Protein: Tau
Gene Symbol: Mapt
Protein Id: P19332
Protein Name: TAU_RAT
PTM: phosphorylation
Site: Ser202
Site Sequence: QKEAWGKDRLGSEEEVDEDIT
Disease Category: Nervous system diseases
Disease: Cognitive Abnormalities
Disease Subtype: "Cognitive Decline, anesthetic-related"
Disease Cellline:
Disease Info:
Drug: BPV (pic)
Drug Info: "Insufficient information to provide a detailed description of ""BPV (pic)""."
Effect: modulate
Effect Info: "The PTEN inhibitor BPV (pic) can reduce NR2B-mediated tau phosphorylation, thereby alleviating cognitive impairment caused by repeated exposure to isoflurane in juveniles, suggesting that PTEN→NR2B→tau is a key regulatory axis."
Note:
Score: 4.0
Pubmed(PMID): 27836791
Sentence Index:
Sentence:

Sequence & Structure:

MAEPRQEFDTMEDQAGDYTMLQDQEGDMDHGLKESPPQPPADDGSEEPGSETSDAKSTPTAEDVTAPLVEERAPDKQATAQSHTEIPEGTTAEEAGIGDTPNMEDQAAGHVTQEPQKVEIFSQSLLVEPGRREGQAPDSGISDWTHQQVPSMSGAPLPPQGLREATHQPLGTRPEDVERSHPASELLWQESPQKEAWGKDRLGSEEEVDEDITMDESSQESPPSQASLAPGTATPQARSVSASGVSGETTSIPGFPAEGSIPLPADFFSKVSAETQASPPEGPGTGPSEEGHEAAPEFTFHVEIKASAPKEQDLEGATVVGAPAEEQKARGPSVGKGTKEASLLEPTDKQPAAGLPGRPVSRVPQLKARVAGVSKDRTGNDEKKAKTSTPSCAKTPSNRPCLSPTRPTPGSSDPLIKPSSPAVCPEPATSPKYVSSVTPRNGSPGTKQMKLKGADGKTGAKIATPRGAATPGQKGTSNATRIPAKTTPSPKTPPGSGEPPKSGERSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSASKSRLQTAPVPMPDLKNVRSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVHIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: