| Id: | acc4947 |
| Group: | 1sens |
| Protein: | VASP |
| Gene Symbol: | Vasp |
| Protein Id: | P70460 |
| Protein Name: | VASP_MOUSE |
| PTM: | phosphorylation |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Pulmonary Hypertension |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | delta-aminolevulinic acid (ALA) |
| Drug Info: | "Delta-aminolevulinic acid (ALA) is a non-proteinogenic amino acid and a key intermediate in the biosynthesis of porphyrins, heme, and chlorophyll. It plays a crucial role in various biological processes and is also used in photodynamic therapy for certain medical conditions." |
| Effect: | modulate |
| Effect Info: | "Under chronic hypoxia, the exogenous H?O? in pulmonary blood vessels increases, accompanied by PKG activation and VASP phosphorylation, which inhibits the pulmonary artery contraction response induced by acute hypoxia. ALA reverses this pathological process by enhancing the PpIX-sGC-PKG signaling pathway, showing potential therapeutic effects on pulmonary arterial hypertension." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 24920729 |
| Sentence Index: | 24920729_8 |
| Sentence: | "ALA generated prolonged detectible increases in PpIX and PKG-associated phosphorylation of VASP, suggesting PKG activation may contribute to suppression of pulmonary hypertension and prevention of alterations in extracellular peroxide that appear to be attenuating HPV responses caused by chronic hypoxia." |
Sequence & Structure:
MSETVICSSRATVMLYDDSNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQQVVINCAIIRGVKYNQATPIFHQWRDARQVWGLNFGSKEDAIQFATGMANALEALEGGGPPPAPAPPAWSAQNGPSPEELEQQKRQPEHMERRVSNAGGPPAPPAGGPPPPPGPPPPPGPPPPPGLPSSGVSGAGHGAGAAPPPAPPLPTAQGPNSGGSGAPGLAAAIAGAKLRKVSKQEEASGGPLAPKAENSRSTGGGLMEEMNAMLARRRKATQVGEKPPKDESASEESEARLPAQSEPVRRPWEKNSTTLPRMKSSSSVTTSEAHPSTPCSSDDSDLERVKQELLEEVRKELQKMKEEIIEVFVQELRKRGSP
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| S | 239 | U | Marfan syndrome | Phosphorylation | 33976159 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
