Id: acc4963
Group: 2sens
Protein: VAV2
Gene Symbol: VAV2
Protein Id: P52735
Protein Name: VAV2_HUMAN
PTM: phosphorylation
Site: Tyr
Site Sequence:
Disease Category: Cancer
Disease: Retinoblastoma
Disease Subtype:
Disease Cellline: WERI-Rb-1
Disease Info:
Drug: Tubeimoside II (TBMS II)
Drug Info: Tubeimoside II (TBMS II) is a natural compound. It has attracted attention in the field of medicine due to its potential pharmacological activities.
Effect: modulate
Effect Info: "TBMS II inhibits the phosphorylation of Vav2 and SRC, and blocks the oxidative cascade reaction involving SRC, Vav2, Rac-1, NOXs, and ROS."
Note:
Score: 4.0
Pubmed(PMID): 33412154
Sentence Index:
Sentence:

Sequence & Structure:

MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDINFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSIAQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEVQQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No intensity data of this site,
show all other sites!

VAV2-Ser387
Cancer Intensity
BRCA
COAD
HGSC
ccRCC 0.707
GBM
HNSC
LUAD -0.707
LUSC
non_ccRCC
PDAC
UCEC
VAV2-Ser566
Cancer Intensity
BRCA
COAD 0.707
HGSC
ccRCC
GBM
HNSC
LUAD -0.707
LUSC
non_ccRCC
PDAC
UCEC
VAV2-Ser573
Cancer Intensity
BRCA
COAD
HGSC
ccRCC
GBM 0.962
HNSC
LUAD -1.034
LUSC 0.072
non_ccRCC
PDAC
UCEC
VAV2-Ser649
Cancer Intensity
BRCA
COAD
HGSC
ccRCC
GBM 0.707
HNSC
LUAD -0.707
LUSC
non_ccRCC
PDAC
UCEC
VAV2-Ser653
Cancer Intensity
BRCA -2.229
COAD 0.641
HGSC
ccRCC 0.414
GBM 0.524
HNSC -0.827
LUAD 0.381
LUSC 1.14
non_ccRCC -0.171
PDAC 0.127
UCEC
VAV2-Ser682
Cancer Intensity
BRCA
COAD
HGSC
ccRCC 0.839
GBM 0.797
HNSC
LUAD
LUSC
non_ccRCC
PDAC -1.22
UCEC -0.417
VAV2-Ser768
Cancer Intensity
BRCA
COAD
HGSC
ccRCC
GBM 1.154
HNSC -0.614
LUAD 0.486
LUSC
non_ccRCC
PDAC
UCEC -1.026
VAV2-Ser769
Cancer Intensity
BRCA
COAD
HGSC 1.108
ccRCC 0.079
GBM
HNSC -0.047
LUAD 0.458
LUSC
non_ccRCC
PDAC
UCEC -1.598
VAV2-Ser771
Cancer Intensity
BRCA -1.896
COAD -1.089
HGSC 1.646
ccRCC -0.005
GBM -0.122
HNSC 0.073
LUAD 0.584
LUSC 0.821
non_ccRCC 0.903
PDAC -0.109
UCEC -0.806
VAV2-Ser91
Cancer Intensity
BRCA
COAD
HGSC
ccRCC 0.172
GBM
HNSC 0.903
LUAD
LUSC -1.075
non_ccRCC
PDAC
UCEC

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: