Id: acc4989
Group: 1sens
Protein: Survivin
Gene Symbol: BIRC5
Protein Id: O15392
Protein Name: BIRC5_HUMAN
PTM: ubiquitination
Site: unclear
Site Sequence:
Disease Category: Cancer
Disease: Lung Cancer
Disease Subtype:
Disease Cellline: A549
Disease Info:
Drug: IITZ-01
Drug Info: "IITZ - 01 is a drug. However, due to limited information, a more detailed academic description cannot be provided. "
Effect: enhance
Effect Info: "IITZ-01 inhibits the expression of deubiquitinating enzyme USP9X, promotes the ubiquitination and degradation of Survivin, and sensitizes to TRAIL."
Note:
Score: 5.0
Pubmed(PMID): 32825566
Sentence Index:
Sentence:

Sequence & Structure:

MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRRAIEQLAAMD

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

Target Drug name MOA Phase Status Disease Source
BIRC5 GATAPARSEN Survivin mRNA antisense inhibitor 2 Completed acute myeloid leukemia ClinicalTrials
BIRC5 SVN53-67/M57-KLH PEPTIDE VACCINE Baculoviral IAP repeat-containing protein 5 vaccine antigen 2 Active, not recruiting glioblastoma multiforme ClinicalTrials
ClinicalTrials
BIRC5 GATAPARSEN Survivin mRNA antisense inhibitor 2 Completed non-small cell lung carcinoma ClinicalTrials
BIRC5 GATAPARSEN Survivin mRNA antisense inhibitor 2 Completed prostate cancer ClinicalTrials
BIRC5 GATAPARSEN Survivin mRNA antisense inhibitor 1 Withdrawn hepatocellular carcinoma ClinicalTrials

Note: Only show clinically investigational or approved drugs with protein targets.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: