| Id: | acc4999 |
| Group: | 1sens |
| Protein: | STAT1 |
| Gene Symbol: | Stat1 |
| Protein Id: | P42225 |
| Protein Name: | STAT1_MOUSE |
| PTM: | phosphorylation |
| Site: | Tyr701 |
| Site Sequence: | ELDDPKRTGYIKTELISVSEV |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Nonseptic Shock |
| Disease Subtype: | zymosan-induced |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | tyrphostin AG-490 |
| Drug Info: | Tyrphostin AG - 490 is a potent and selective inhibitor of the Janus kinase 2 (JAK2). It has been widely used in biological research to study JAK - STAT signaling pathways. |
| Effect: | modulate |
| Effect Info: | Tyrphostin AG-490 can inhibit the phosphorylation of STAT3 and STAT1 and alleviate inflammation in zymosan-induced multi-organ inflammatory injury. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 18656556 |
| Sentence Index: | 18656556_5 |
| Sentence: | "The substance attenuated the elevation of creatinine (indicator of renal failure), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and bilirubin (indicators for liver dysfunction) and prevented the accelerated coagulation time." |
Sequence & Structure:
MSQWFELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAAYDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPVQMSMIIYNCLKEERKILENAQRFNQAQEGNIQNTVMLDKQKELDSKVRNVKDQVMCIEQEIKTLEELQDEYDFKCKTSQNREGEANGVAKSDQKQEQLLLHKMFLMLDNKRKEIIHKIRELLNSIELTQNTLINDELVEWKRRQQSACIGGPPNACLDQLQTWFTIVAETLQQIRQQLKKLEELEQKFTYEPDPITKNKQVLSDRTFLLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKSRLLVKLQESNLLTKVKCHFDKDVNEKNTVKGFRKFNILGTHTKVMNMEESTNGSLAAELRHLQLKEQKNAGNRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVTEPRNLSFFLNPPCAWWSQLSEVLSWQFSSVTKRGLNADQLSMLGEKLLGPNAGPDGLIPWTRFCKENINDKNFSFWPWIDTILELIKNDLLCLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDDPKRTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEMSRIVGPEFDSMMSTV
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
