| Id: | acc5030 |
| Group: | 1sens |
| Protein: | NF-kappaB p65 |
| Gene Symbol: | Rela |
| Protein Id: | Q96RU7 |
| Protein Name: | TRIB3_HUMAN |
| PTM: | phosphorylation |
| Site: | Ser536 |
| Site Sequence: | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |
| Disease Category: | Urinary and reproductive system diseases |
| Disease: | Renal Injury |
| Disease Subtype: | hypertensive |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Benazepril |
| Drug Info: | Benazepril is an angiotensin - converting enzyme (ACE) inhibitor. It is commonly used to treat high blood pressure and heart failure by relaxing blood vessels and reducing the workload on the heart. |
| Effect: | modulate |
| Effect Info: | "Phosphorylation of NF-kappaB p65 in rats with hypertensive nephropathy model is inhibited by Benazepril, which alleviates inflammatory signals." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 19018797 |
| Sentence Index: | 19018797_7 |
| Sentence: | "3. Treatment with benazepril inhibited the formation of AngII, reduced SBP and alleviated renal lesions in SHR compared with both untreated SHR and control WKY rats." |
Sequence & Structure:
MRATPLAAPAGSLSRKKRLELDDNLDTERPVQKRARSGPQPRLPPCLLPLSPPTAPDRATAVATASRLGPYVLLEPEEGGRAYQALHCPTGTEYTCKVYPVQEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTHGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWLRQDPMPLAPTRSHLWEAAQVVPDGLGLDEAREEEGDREVVLYG
No data.
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
