| Id: | acc5053 |
| Group: | 1sens |
| Protein: | STAT5 |
| Gene Symbol: | Stat5a |
| Protein Id: | P42230 |
| Protein Name: | STA5A_MOUSE |
| PTM: | phosphorylation |
| Site: | Tyr694 |
| Site Sequence: | PVLAKAVDGYVKPQIKQVVPE |
| Disease Category: | Immune system diseases |
| Disease: | Rheumatoid Arthritis |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | KD025 |
| Drug Info: | "KD025 is a novel small - molecule Rho - associated coiled - coil kinase 2 (ROCK2) inhibitor, which shows potential in treating various diseases through its regulatory effects on cellular processes. " |
| Effect: | modulate |
| Effect Info: | KD025 promotes the suppressive function of Tregs by upregulating STAT5 phosphorylation and Foxp3 expression. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 25385601 |
| Sentence Index: | 25385601_3 |
| Sentence: | "Pharmacological inhibition with KD025 or siRNA-mediated inhibition of ROCK2, but not ROCK1, significantly diminished STAT3 phosphorylation and binding to IL-17 and IL-21 promoters and reduced IFN regulatory factor 4 and nuclear hormone RAR-related orphan receptor gammat protein levels in T cells derived from healthy subjects or rheumatoid arthritis patients." |
Sequence & Structure:
MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRGQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVREANNCSSPAGVLVDAMSQKHLQINQRFEELRLITQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLGQLNPQERMSRETALQQKQVSLETWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNISSNHLEDYNSMSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPDRNLWNLKPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVFAKYYTPVLAKAVDGYVKPQIKQVVPEFVNASTDAGASATYMDQAPSPVVCPQPHYNMYPPNPDPVLDQDGEFDLDESMDVARHVEELLRRPMDSLDARLSPPAGLFTSARSSLS
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
