Id: acc5070
Group: 1sens
Protein: c-Jun
Gene Symbol: JUN
Protein Id: P05412
Protein Name: JUN_HUMAN
PTM: acetylation
Site: unclear
Site Sequence:
Disease Category: Immune system diseases
Disease: Rheumatoid Arthritis
Disease Subtype:
Disease Cellline:
Disease Info:
Drug: Resveratrol
Drug Info: "Resveratrol is a polyphenolic compound found in various plants, such as grapes and peanuts. It has antioxidant and anti - inflammatory properties and is being researched for potential health benefits including cardiovascular protection and anti - aging effects."
Effect: modulate
Effect Info: "BK induces the acetylation of NF-kappaB p65 and AP-1 (c-Jun/c-Fos), further increasing their binding ability to the COX-3 promoter, thereby amplifying the inflammatory response."
Note: inducer
Score: 4.0
Pubmed(PMID): 28288820
Sentence Index:
Sentence:

Sequence & Structure:

MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No intensity data of this site,
show all other sites!

JUNB-Lys240
Cancer Intensity
BRCA -1.141
COAD
HGSC
ccRCC
GBM
HNSC
LUAD 0.726
LUSC 0.415
non_ccRCC
PDAC
UCEC
JUNB-Lys284
Cancer Intensity
BRCA -0.707
COAD
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC 0.707
non_ccRCC
PDAC
UCEC
JUNB-Lys36
Cancer Intensity
BRCA 0.085
COAD
HGSC
ccRCC
GBM
HNSC
LUAD -1.04
LUSC 0.955
non_ccRCC
PDAC
UCEC

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
- - D Airway fibrosis Acetylation 34011384
- - P Myeloma Phosphorylation 23175437
- - U Airway fibrosis Acetylation 34011384
- - U Osteogenic sarcoma/osteosarcoma Phosphorylation 24025361

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: