Id: acc5071
Group: 1sens
Protein: c-Fos
Gene Symbol: FOS
Protein Id: P01100
Protein Name: FOS_HUMAN
PTM: acetylation
Site: unclear
Site Sequence:
Disease Category: Immune system diseases
Disease: Rheumatoid Arthritis
Disease Subtype:
Disease Cellline:
Disease Info:
Drug: Resveratrol
Drug Info: "Resveratrol is a polyphenolic compound found in various plants, such as grapes and peanuts. It has antioxidant and anti - inflammatory properties and is being researched for potential health benefits including cardiovascular protection and anti - aging effects."
Effect: modulate
Effect Info: "BK induces the acetylation of NF-kappaB p65 and AP-1 (c-Jun/c-Fos), further increasing their binding ability to the COX-3 promoter, thereby amplifying the inflammatory response."
Note: inducer
Score: 4.0
Pubmed(PMID): 28288820
Sentence Index:
Sentence:

Sequence & Structure:

MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANFIPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFTLPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYAADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No intensity data of this site,
show all other sites!

FOS-Lys113
Cancer Intensity
BRCA -0.27
COAD
HGSC
ccRCC
GBM
HNSC
LUAD -0.837
LUSC 1.107
non_ccRCC
PDAC
UCEC
FOS-Lys128
Cancer Intensity
BRCA -1.155
COAD
HGSC
ccRCC
GBM
HNSC
LUAD 0.581
LUSC 0.574
non_ccRCC
PDAC
UCEC
FOSL2-Lys222
Cancer Intensity
BRCA -1.405
COAD
HGSC
ccRCC
GBM -0.119
HNSC
LUAD -0.355
LUSC 0.694
non_ccRCC
PDAC
UCEC 1.185
FOSL2-Lys240
Cancer Intensity
BRCA -1.324
COAD
HGSC
ccRCC
GBM 1.178
HNSC
LUAD -0.655
LUSC 0.167
non_ccRCC
PDAC
UCEC 0.634

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: