Id: acc5104
Group: 2sens
Protein: histone H3
Gene Symbol: H3C1
Protein Id: P68431
Protein Name: H31_HUMAN
PTM: acetylation
Site: unclear
Site Sequence:
Disease Category: Cancer
Disease: Lung Cancer
Disease Subtype: small cell lung carcinomas (SCLCs)
Disease Cellline: U1906
Disease Info:
Drug: Decitabine + VPA
Drug Info: "Decitabine is a hypomethylating agent that inhibits DNA methyltransferase, which can be used in the treatment of myelodysplastic syndromes and acute myeloid leukemia. | Valproic acid (VPA) is a histone deacetylase inhibitor and an antiepileptic drug, which can also have effects on gene expression regulation."
Effect: modulate
Effect Info: "The synergistic effect of VPA and decitabine promotes strong and persistent histone acetylation, inhibits DNMT, restores the expression of caspase-8, and ultimately enhances the sensitivity of SCLC cells to TRAIL."
Note: "drug comb,histone"
Score: 3.0
Pubmed(PMID): 21771726
Sentence Index:
Sentence:

Sequence & Structure:

MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
K 27 A Oligodendroglioma Methylation 34020723
K 4 D Breast cancer Methylation 19943104
K 27 D Cervical intraepithelial neoplasia Acetylation 28716899
K 27 D Ovarian cancer Methylation 20053926
K 27 D Malignant peripheral nerve sheath tumor Methylation 28752843
K 27 D Autism spectrum disorder Methylation 23423141
K 4 D Lung cancer Methylation 26301496
K 4 D Liver cancer Methylation 26301496
K 4 D Breast cancer Methylation 26301496
K 27 D Acute myelogenous leukemia Methylation 22897849
K 4 D Fragile X syndrome Methylation 18628788
K 4 D Oral squamous cell carcinoma Methylation 19753335
K 4 D Prostate cancer Methylation 19739128
K 18 D Pancreatic carcinoma Methylation 20142597
K 18 D Hepatocellular carcinoma Acetylation 25613642
K 9 D Prostate cancer Methylation 19739128
K 9 D Pancreatic carcinoma Methylation 20142597
K 4 D Pancreatic carcinoma Methylation 20142597
K 27 D Systemic lupus erythematosus Methylation 36165173
K 9 D Diabetes mellitus Acetylation 23423566
K 9 D Friedreich's ataxia Acetylation 18045775
K 9 D Prostate cancer Acetylation 19885564
K 9 D Systemic lupus erythematosus Acetylation 36165173
S 10 D Breast cancer Phosphorylation 21146603
K 14 D Cervical intraepithelial neoplasia Acetylation 28716899
K 14 D Prostate cancer Acetylation 19885564
K 18 D Prostate cancer Acetylation 19885564
K 14 D Systemic lupus erythematosus Acetylation 36165173
K 23 D Prostate cancer Acetylation 19885564
K 27 U Follicular lymphoma Methylation 35661922
T 11 U Prostate cancer Phosphorylation 18066052
K 4 U Bile duct cancer Methylation 19896696
K 4 U Gastric cancer Methylation 19896696
K 4 U Neuroendocrine cancer Methylation 19896696
K 4 U Pancreatic ductal adenocarcinoma Methylation 19896696
T 6 U Prostate cancer Phosphorylation 20228790
K 9 U Friedreich's ataxia Methylation 18045775
K 4 U Oral squamous cell carcinoma Methylation 19753335
S 10 U Breast adenocarcinoma Phosphorylation 16461563
K 27 U Pediatric-type follicular lymphoma Methylation 35661922
K 27 U Primary cutaneous follicle center cell lymphoma Methylation 35661922
K 79 U Leukemia Methylation 23361907
K 9 U Friedreich's ataxia Methylation 18045775
K 4 U Autism spectrum disorder Methylation 23423141
K 56 U Colorectal cancer Acetylation 19270680
K 9 U Prostate cancer Acetylation 19935671
K 4 U Marfan syndrome Acetylation 20829218
K 9 U Diabetes mellitus Acetylation 23423566
K 9 U Gastric adenocarcinoma Acetylation 18470569
K 9 U Type 2 diabetes Acetylation 34944721
K 14 U Marfan syndrome Acetylation 20829218
K 18 U Colorectal cancer Acetylation 19057998
K 18 U Esophageal carcinoma Acetylation 20142251
K 27 U Anaplastic large cell lymphoma Acetylation 22899583
K 27 U Melanoma Acetylation 32079144
K 27 U Merkel cell carcinoma Acetylation 25941994
K 56 U Astrocytoma Acetylation 19270680
K 4 U Prostate cancer Methylation 19935671
K 56 U Glioma Acetylation 19270680
K 56 U Laryngeal cancer Acetylation 19270680
K 56 U Oligodendroglioma Acetylation 19270680
K 56 U Testicular cancer Acetylation 19270680
K 56 U Thyroid cancer Acetylation 19270680
K 36 U Acute myelogenous leukemia Methylation 17589499
K 4 U Marfan syndrome Methylation 20829218
K 9 U Breast cancer Methylation 19943104
K 27 U Fragile X syndrome Methylation 18628788
K 36 U Clear cell kidney cancer Methylation 28754676
K 79 U Acute lymphocytic leukemia Methylation 18977325
K 79 U Lung cancer Methylation 22190683

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: