Id: acc5108
Group: 1sens
Protein: Ribosomal protein S6
Gene Symbol: Rps6
Protein Id: P62755
Protein Name: RS6_RAT
PTM: phosphorylation
Site: Ser236
Site Sequence: QIAKRRRLSSLRASTSKSESS
Disease Category: Nervous system diseases
Disease: Spinal Cord Injury
Disease Subtype:
Disease Cellline:
Disease Info:
Drug: bisperoxovanadium (bpV)
Drug Info: "Bisperoxovanadium (bpV) is a vanadium - based compound. It has been studied for its potential biological activities, such as insulin - mimetic and anti - cancer properties. "
Effect: modulate
Effect Info: "bpV promotes the phosphorylation of S6 protein and enhances the protein synthesis signal downstream of mTOR, potentially participating in the process of neural protection and repair."
Note:
Score: 4.0
Pubmed(PMID): 30672370
Sentence Index:
Sentence:

Sequence & Structure:

MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
- - P Ascites hepatoma Phosphorylation 2852063
- - U Hepatocellular carcinoma/hepatocarcinoma/hepatoma Phosphorylation 6319390

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: