| Id: | acc5119 |
| Group: | 1sens |
| Protein: | ERK1 |
| Gene Symbol: | Mapk3 |
| Protein Id: | P21708 |
| Protein Name: | MK03_RAT |
| PTM: | phosphorylation |
| Site: | Thr202 |
| Site Sequence: | DPEHDHTGFLTEYVATRWYRA |
| Disease Category: | Nervous system diseases |
| Disease: | Status Epilepticus |
| Disease Subtype: | neuronal death |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Leptomycin B (LMB) + Cyclosporin A (CsA) |
| Drug Info: | "Leptomycin B (LMB) is a natural product and a potent inhibitor of exportin 1 (CRM1), which plays a crucial role in nuclear export of proteins. | Cyclosporin A (CsA) is a cyclic undecapeptide and a well - known immunosuppressive agent that acts by inhibiting calcineurin, thereby interfering with T - cell activation. " |
| Effect: | modulate |
| Effect Info: | "LMB can upregulate the phosphorylation of PKA and PP2B, activate PKA, inhibit PP2B, and then upregulate ERK1/2, thereby exerting a neuroprotective effect. Combining with CsA can further enhance the phosphorylation of ERK and strengthen the effect of LMB." |
| Note: | drug comb |
| Score: | 4.0 |
| Pubmed(PMID): | 28601633 |
| Sentence Index: | 28601633_8 |
| Sentence: | U0126 (an ERK1/2 inhibitor) co-treatment abolished the protective effect of LMB on SE-induced neuronal death without alterations in PKA and PP2B phosphorylations. |
Sequence & Structure:
MAAAAAAPGGGGGEPRGTAGVVPVVPGEVEVVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFDMELDDLPKERLKELIFQETARFQPGAPEAP
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| T | 203 | D | Major depressive disorder | Phosphorylation | 16959794 |
| Y | 205 | D | Major depressive disorder | Phosphorylation | 16959794 |
| T | 203 | U | Uteroplacental insufficiency | Phosphorylation | 16940436 |
| Y | 205 | U | Uteroplacental insufficiency | Phosphorylation | 16940436 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
