| Id: | acc5145 |
| Group: | 1sens |
| Protein: | IRAK4 |
| Gene Symbol: | Irak4 |
| Protein Id: | Q8R4K2 |
| Protein Name: | IRAK4_MOUSE |
| PTM: | phosphorylation |
| Site: | Thr345 |
| Site Sequence: | SARLAQTVMTSRIVGTTAYMA |
| Disease Category: | Nervous system diseases |
| Disease: | Traumatic Brain Injury |
| Disease Subtype: | neurological deficit |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | PF-0665083 |
| Drug Info: | "PF-0665083 is a specific drug. However, without more detailed information, a comprehensive academic description cannot be provided." |
| Effect: | modulate |
| Effect Info: | "PF-0665083 inhibits IRAK4 phosphorylation and alleviates secondary injuries induced by CCI, including neuroinflammation, neuronal apoptosis, and BBB damage." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 35149117 |
| Sentence Index: | 35149117_8 |
| Sentence: | "Interestingly, PF-0665083, an IRAK4 inhibitor, inhibits phosphorylation of IRAK4 and attenuates CCI-induced secondary injury." |
Sequence & Structure:
MNKPLTPSTYIRNLNVGILRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTCELLFDWGTTNCTVGDLVDLLVQIELFAPATLLLPDAVPQTVKSLPPREAATVAQTHGPCQEKDRTSVMPMPKLEHSCEPPDSSSPDNRSVESSDTRFHSFSFHELKSITNNFDEQPASAGGNRMGEGGFGVVYKGCVNNTIVAVKKLGAMVEISTEELKQQFDQEIKVMATCQHENLVELLGFSSDSDNLCLVYAYMPNGSLLDRLSCLDGTPPLSWHTRCKVAQGTANGIRFLHENHHIHRDIKSANILLDKDFTAKISDFGLARASARLAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLELITGLAAVDENREPQLLLDIKEEIEDEEKTIEDYTDEKMSDADPASVEAMYSAASQCLHEKKNRRPDIAKVQQLLQEMSA
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
