Id: | acc5146 |
Group: | 1sens |
Protein: | TAK1 |
Gene Symbol: | Map3k7 |
Protein Id: | Q62073 |
Protein Name: | M3K7_MOUSE |
PTM: | phosphorylation |
Site: | unclear |
Site Sequence: | |
Disease Category: | Nervous system diseases |
Disease: | Traumatic Brain Injury |
Disease Subtype: | neurological deficit |
Disease Cellline: | |
Disease Info: | |
Drug: | PF-0665083 |
Drug Info: | "PF-0665083 is a specific drug. However, without more detailed information, a comprehensive academic description cannot be provided." |
Effect: | modulate |
Effect Info: | "IRAK4 exacerbates secondary injury in traumatic brain injury (TBI) by promoting the activation of TAK1 and activates the downstream inflammatory cascade reaction, which can be alleviated by PF - 0665083." |
Note: | |
Score: | 4.0 |
Pubmed(PMID): | 35149117 |
Sentence Index: | 35149117_8 |
Sentence: | "Interestingly, PF-0665083, an IRAK4 inhibitor, inhibits phosphorylation of IRAK4 and attenuates CCI-induced secondary injury." |
Sequence & Structure:
MSTASAASSSSSSSASEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIVATAGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPARSHPWTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.