Id: acc5148
Group: 1sens
Protein: TAK1
Gene Symbol: Map3k7
Protein Id: Q62073
Protein Name: M3K7_MOUSE
PTM: phosphorylation
Site: unclear
Site Sequence:
Disease Category: Nervous system diseases
Disease: Traumatic Brain Injury
Disease Subtype: neurological deficit
Disease Cellline:
Disease Info:
Drug: IRAK4 KO
Drug Info: IRAK4 KO refers to the knockout of the interleukin - 1 receptor - associated kinase 4 (IRAK4) gene. This genetic modification is used in research to understand the role of IRAK4 in biological processes and potential therapeutic applications.
Effect: modulate
Effect Info: "siRNA-mediated inhibition of IRAK4 can significantly alleviate neuroinflammation, neuronal apoptosis, cerebral edema, and blood-brain barrier (BBB) dysfunction and improve neurological deficits. Mechanistically, IRAK4 exacerbates controlled cortical impact (CCI) by activating the TAK1 signaling pathway."
Note: Non-conventional drugs
Score: 3.0
Pubmed(PMID): 35149117
Sentence Index:
Sentence:

Sequence & Structure:

MSTASAASSSSSSSASEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIVATAGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPARSHPWTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: