Id: acc5156
Group: 1sens
Protein: ERK1
Gene Symbol: Mapk3
Protein Id: Q63844
Protein Name: MK03_MOUSE
PTM: phosphorylation
Site: Thr202
Site Sequence: DPEHDHTGFLTEYVATRWYRA
Disease Category: Nervous system diseases
Disease: Seizures
Disease Subtype: kainic acid induced
Disease Cellline:
Disease Info:
Drug: topiramate (TPM)
Drug Info: "Topiramate (TPM) is an antiepileptic drug. It is also used in the prophylaxis of migraine headaches, acting through multiple mechanisms including the modulation of ion channels and neurotransmitter systems. "
Effect: modulate
Effect Info: "TPM inhibits KA-induced ERK phosphorylation, which mainly occurs in the hippocampal CA3 region. It may attenuate the ERK-mediated cell death signals, thereby protecting neurons."
Note:
Score: 4.0
Pubmed(PMID): 17868053
Sentence Index:
Sentence:

Sequence & Structure:

MAAAAAAPGGGGGEPRGTAGVVPVVPGEVEVVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFDMELDDLPKERLKELIFQETARFQPGAPEGP

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
T 203 U Squamous cell carcinoma Phosphorylation 19934324

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: