| Id: | acc5163 |
| Group: | 1sens |
| Protein: | cTnI |
| Gene Symbol: | Tnni3 |
| Protein Id: | P48787 |
| Protein Name: | TNNI3_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser23 |
| Site Sequence: | PAPAPVRRRSSANYRAYATEP |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Cardiac Dysfunction |
| Disease Subtype: | Sepsis-Associated Cardiac Dysfunction |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Cyclopentyladenosine |
| Drug Info: | Cyclopentyladenosine is a potent adenosine receptor agonist. It has potential applications in the study of adenosine - mediated physiological processes due to its specific binding affinity to adenosine receptors. |
| Effect: | modulate |
| Effect Info: | "LPS induces a continuous increase in the phosphorylation of Ser23/24 of cardiac troponin I (cTnI) in the myocardium, leading to a decrease in myofilament Ca?? sensitivity and causing myocardial systolic dysfunction. This phenomenon can be reversed by Cyclopentyladenosine." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 19201758 |
| Sentence Index: | 19201758_1 |
| Sentence: | AIMS: Sepsis-associated cardiac dysfunction represents an intrinsic impairment of cardiomyocyte function due in part to a decrease in myofilament Ca(2+) sensitivity associated with a sustained increase in cardiac troponin I (cTnI) phosphorylation at Ser23/24. |
Sequence & Structure:
MADESSDAAGEPQPAPAPVRRRSSANYRAYATEPHAKKKSKISASRKLQLKTLMLQIAKQEMEREAEERRGEKGRVLRTRCQPLELDGLGFEELQDLCRQLHARVDKVDEERYDVEAKVTKNITEIADLTQKIYDLRGKFKRPTLRRVRISADAMMQALLGTRAKESLDLRAHLKQVKKEDIEKENREVGDWRKNIDALSGMEGRKKKFEG
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
