Id: acc5172
Group: 1sens
Protein: NF-kappaB p65
Gene Symbol: Rela
Protein Id: Q04207
Protein Name: TF65_MOUSE
PTM: phosphorylation
Site: Ser536
Site Sequence: SGDEDFSSIADMDFSALLSQI
Disease Category: Urinary and reproductive system diseases
Disease: Acute Kidney Injury
Disease Subtype: septic acute kidney injury
Disease Cellline:
Disease Info:
Drug: Dimethyl fumarate (DMF)
Drug Info: Dimethyl fumarate (DMF) is an ester of fumaric acid. It is used in the treatment of multiple sclerosis and psoriasis.
Effect: modulate
Effect Info: "DMF alleviates lipopolysaccharide (LPS)-induced acute kidney injury and inflammatory responses by inhibiting the phosphorylation and nuclear translocation of NF-kappaB p65, suppressing the expression of pro-inflammatory factors (TNF-alpha, IL-6) and enhancing the expression of anti-inflammatory factors (IL-10, Arg-1) in bone marrow-derived macrophages (BMDMs)."
Note:
Score: 4.0
Pubmed(PMID): 34915410
Sentence Index:
Sentence:

Sequence & Structure:

MDDLFPLIFPSEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGYYEADLCPDRSIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFHVPIEEQRGDYDLNAVRLCFQVTVRDPAGRPLLLTPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFNGPTEPRPPTRRIAVPTRNSTSVPKPAPQPYTFPASLSTINFDEFSPMLLPSGQISNQALALAPSSAPVLAQTMVPSSAMVPLAQPPAPAPVLTPGPPQSLSAPVPKSTQAGEGTLSEALLHLQFDADEDLGALLGNSTDPGVFTDLASVDNSEFQQLLNQGVSMSHSTAEPMLMEYPEAITRLVTGSQRPPDPAPTPLGTSGLPNGLSGDEDFSSIADMDFSALLSQISS

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: