Id: | acc5183 |
Group: | 1sens |
Protein: | STAT3 |
Gene Symbol: | Stat3 |
Protein Id: | P42227 |
Protein Name: | STAT3_MOUSE |
PTM: | phosphorylation |
Site: | Tyr705 |
Site Sequence: | EADPGSAAPYLKTKFICVTPT |
Disease Category: | Cardiovascular and circulatory system diseases |
Disease: | Cardiomyopathy |
Disease Subtype: | septic cardiomyopathy |
Disease Cellline: | |
Disease Info: | |
Drug: | Electroacupuncture (EA) |
Drug Info: | Electroacupuncture (EA) is a form of acupuncture where a small electric current is passed between pairs of acupuncture needles. It combines traditional acupuncture with modern electrical stimulation methods to enhance therapeutic effects. |
Effect: | modulate |
Effect Info: | "Electroacupuncture pretreatment can inhibit sepsis-induced STAT3 phosphorylation, reduce the levels of inflammatory factors (TNF-alpha, IL-6, IL-1beta) and myocardial cell apoptosis, thereby exerting anti-inflammatory and cardioprotective effects, which are mainly achieved by inhibiting the calpain-2/STAT3 signaling pathway." |
Note: | Non-conventional drugs |
Score: | 3.0 |
Pubmed(PMID): | 36160853 |
Sentence Index: | 36160853_10 |
Sentence: | "Additionally, inhibition of calpain-2 expression using the corresponding siRNA decreased the Phosphorylation of STAT3,pro-inflammatory factors and apoptosis in lipopolysaccharide- treated cardiomyocytes, confirming that calpain-2 activated p-STAT3 participate in septic cardiomyopathy." |
Sequence & Structure:
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMDLTSECATSPM
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDResidue | Position | State | Disease | Class | PMID |
---|---|---|---|---|---|
Y | 705 | U | Neurofibromatosis | Phosphorylation | 23318430 |
Y | 705 | U | Squamous cell carcinoma | Phosphorylation | 19934324 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.